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ATLAS Biolabs - Laboratory services

Laboratory services

ATLAS Biolabs offers molecular genetic services. These services include next-generation sequencing (NGS) and the analysis of microarrays as well as high-quality bioinformatic data analyses upon request. In addition to human samples, we also process biomaterial of common model organisms, such as mouse, rat, zebrafish, Drosophila etc. Furthermore, we analyse DNA and RNA of farm animals, plants (agrigenomics) as well as domestic animals and microorganisms.


Exomes for general and clinical purposes

You have special disease-related questions? We offer exome sequencing from IDT, Illumina and Agilent, or alternatively panels with a focus on disease-relevant target regions. These are derived from the HGMD, OMIM and ClinVar databases and possess significantly higher coverage and significance compared to whole exome sequencing.

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Digital molecular karyotyping

The causes of genetic diseases can be identified by digital karyotyping, such as copy number variations (CNV), amplifications, deletions, loss of heterozygosity (LOH) or copy-number-neutral LOH (uniparental disomy). Karyotyping based on oligonucleotides using microarrays is characterised by a very high resolution with distances of a few kilobase (kb) only. Depending on the type of microarray, the probes are located at an average distance of 1 kb. We use technologies from Thermo Fisher Scientific/Affymetrix, such as CytoScan and Agilent Technologies (CGH, SurePrint).

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Oncogene analyses

We analyse the DNA of your FFPE material using the OncoScan FFPE assay kit (Thermo Fisher Scientific/Affymetrix). This kit ensures a very high resolution (50-100 kb) of the DNA of more than 900 cancer genes. It also allows the analysis of somatic mutations. The dynamic range is 10 copies or more. The method furthermore allows the genome-wide analysis of copy number variations (CNV) and loss of heterozygosity (LOH).

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Pharmacogenetics

Our focus is also on genetic variations that are influenced by drug uptake or absorption, distribution, metabolism and excretion (ADME). For these cases, ATLAS Biolabs uses special technologies for the investigation of pharmacogenetically relevant genes and markers (PGx), e.g. the Thermo Fisher Scientific/Axiom PharmacoScan.

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Microbiome analyses

Microbiome analyses should be considered for analysing microbial communities. These communities, found, for example, in the intestines of humans and animals, but also in plants, have a manifold influence on metabolism and thus on further processes.

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Transcriptome analyses

Transcriptome analyses provide a better understanding of how the genome is transformed into functional proteins. Their clinical benefit is that they permit expression profiles to be classified, which also constitutes a meaningful contribution to individualised medicine. We offer two powerful technologies for transcriptome analysis: hybridisation-based microarray technology and RNA sequencing.

More about transcriptome analyses